To live or to die: a matter of processing damaged DNA termini in neurons
نویسنده
چکیده
Defects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecular mechanisms of some of the DNA end processing activities are reviewed and the association with human neurodegenerative disease is discussed.
منابع مشابه
Synaptophysin-Positive Neurons in External And Extreme Capsules in Human Brain
Purpose: Externaland extreme capsules are parts of cerebral white matter, and accordingto the classic knowledge they must have no neuronal cell bodies.This researchis designedto find neurons in the external and extreme capsules, and to determine that these neurons are functional or aberrant. Materitais and Methods: Ten adult normal human brains from both sexes were studied using 15,µm serial c...
متن کاملبررسی اثر DNA آسیب دیده با داروی آلکیله کننده ملفالان بر میزان و کیفیت شاخصهای بلوغ و جهت گیری فنوتیپ های ایمنی سلولهای دندرتیک
Background & Aims: Dendritic cells are the most potent antigen presenting cells in induction or polarization of T-dependent immune responses. In cancerous patients, suppressive or detoured immune responses regard to tumor cells, prevent appropriate functions of dendritic cells. Nowadays, in vitro production, expansion and maturation of dendritic cells in presence of safe maturation factors whi...
متن کاملTracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3′-phosphoglycolate termini in SCAN1 cells
To track the processing of damaged DNA double-strand break (DSB) ends in vivo, a method was devised for quantitative measurement of 3'-phosphoglycolate (PG) termini on DSBs induced by the non-protein chromophore of neocarzinostatin (NCS-C) in the human Alu repeat. Following exposure of cells to NCS-C, DNA was isolated, and labile lesions were chemically stabilized. All 3'-phosphate and 3'-hydro...
متن کاملP116: The Relationship between Spinal Cord Injury and Neuroinflammation and Treatment Methods
Spinal cord injury (SCI) is usually caused by a physical factor, especially like burst fracture. Its primary phase involves displacement and physical accidents for the spinal cord, which have two factors of depth and speed of impact. In this phase, most damaged cells are oligodendrocytes in white matter. The secondary phase involves a cascade of cellular and molecular events that progresses rap...
متن کاملStructural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Polynucleotide kinase/phosphatase (PNKP) is a critical mammalian DNA repair enzyme that generates 5'-phosphate and 3'-hydroxyl groups at damaged DNA termini that are required for subsequent processing by DNA ligases and polymerases. The PNKP phosphatase domain recognizes 3'-phosphate termini within DNA nicks, gaps, or at double- or single-strand breaks. Here we present a mechanistic rationale f...
متن کامل